发明申请
- 专利标题: DROSPIRENONE FOR HORMONE REPLACEMENT THERAPY
- 专利标题(中): 用于激素替代治疗的DROSPIRENONE
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申请号: US13356005申请日: 2012-01-23
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公开(公告)号: US20120220556A1公开(公告)日: 2012-08-30
- 发明人: Wolfgang HEIL , Juergen Hilmann , Ralph Lipp , Rolf Schuermann
- 申请人: Wolfgang HEIL , Juergen Hilmann , Ralph Lipp , Rolf Schuermann
- 主分类号: A61K31/585
- IPC分类号: A61K31/585 ; A61P25/00 ; A61P15/00 ; A61P9/00 ; A61P19/10 ; A61P17/00 ; A61P5/30 ; A61P25/22
摘要:
A pharmaceutical composition comprising as a first active ingredient an estrogen, such as estradiol or estradiol valerate, in sufficient amounts to treat disorders and symptoms associated with deficient endogenous levels of estrogen in women, and as a second active ingredient 6β,7β;15β;16β-dimethylene-3-oxo-17α-preg-4-ene-21,17-carbolactone (drospirenone, DRSP) in sufficient amounts to protect the endometrium from the adverse effects of estrogen is useful for, amongst others, treating peri-menopausal, menopausal and post-menopausal women. This composition may be used for hormone replacement therapy and may be administered as a multi-phased pharmaceutical preparation. This combination therapy may comprise continuous, sequential or interrupted administration, or combinations thereof, of DRSP and estrogen, each optionally in micronized form.