发明申请
US20120220583A1 SUBSTITUTED HYDROXYETHYL AMINE COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE
有权
取代的羟基乙胺化合物作为β-分泌酶调节剂和使用方法
- 专利标题： SUBSTITUTED HYDROXYETHYL AMINE COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE
- 专利标题（中）： 取代的羟基乙胺化合物作为β-分泌酶调节剂和使用方法
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申请号： US13410201申请日： 2012-03-01
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公开(公告)号： US20120220583A1公开(公告)日： 2012-08-30
- 发明人: Wenge ZHONG , Stephen HITCHCOCK , Vinod F. PATEL , Michael CROGHAN , Thomas DINEEN , Scott HARRIED , Daniel HORNE , Ted JUDD , Matthew KALLER , Charles KREIMAN , Patricia LOPEZ , Holger MONENSCHEIN , Thomas NGUYEN , Matthew WEISS , Qiufen XUE , Bryant YANG , Russell GRACEFFA
- 申请人： Wenge ZHONG , Stephen HITCHCOCK , Vinod F. PATEL , Michael CROGHAN , Thomas DINEEN , Scott HARRIED , Daniel HORNE , Ted JUDD , Matthew KALLER , Charles KREIMAN , Patricia LOPEZ , Holger MONENSCHEIN , Thomas NGUYEN , Matthew WEISS , Qiufen XUE , Bryant YANG , Russell GRACEFFA
- 申请人地址： US CA Thousand Oaks
- 专利权人： AMGEN INC.
- 当前专利权人： AMGEN INC.
- 当前专利权人地址： US CA Thousand Oaks
- 主分类号： A61K31/438
- IPC分类号： A61K31/438 ; C07D495/10 ; A61P25/00 ; A61K31/5377 ; A61P25/28 ; C07D471/10 ; C07D491/107
摘要：
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase activity and for the treatment of diseases, including Alzheimer's disease (AD) and related CNS conditions, mediated thereby. In one embodiment, the compounds have a general Formula I or Formula II wherein R1a-1c, B, R3-5 and W of Formula I, and R1a-1c, R2-5, A1-4, W, X, Z, m and n of Formula II are defined herein. The invention further provides compounds of Formula III and IV and sub-Formulas II-A-II-D and III-A-III-D. The compounds may be used in pharmaceutical compositions for treating, prophylactically or therapeutically, disorders related to the activity of beta-secretase protein, including without limitation, AD, cognitive deficits and impairment, schizophrenia and other similar central nervous system conditions.
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