发明申请
- 专利标题： PROCESS FOR TRIPHOSPHATE OLIGONUCLEOTIDE SYNTHESIS
- 专利标题（中）： 磷酸二氢钠合成方法
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申请号： US13393851申请日： 2009-12-22
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公开(公告)号： US20120220761A1公开(公告)日： 2012-08-30
- 发明人: Ivan Zlatev , Francois Morvan , Jean-Jacques Vasseur , Francoise Debart , Muthiah Manoharan
- 申请人： Ivan Zlatev , Francois Morvan , Jean-Jacques Vasseur , Francoise Debart , Muthiah Manoharan
- 申请人地址： US MA Cambridge
- 专利权人： ALNYLAM PHARMACEUTICALS, INC.
- 当前专利权人： ALNYLAM PHARMACEUTICALS, INC.
- 当前专利权人地址： US MA Cambridge
- 优先权： USPCTUS20090055775 20090902
- 国际申请： PCT/US09/69201 WO 20091222
- 主分类号： C07H1/04
- IPC分类号： C07H1/04
摘要：
The present invention describes simple, efficient, and enzyme-free method of making oligonucleotides with 5′-triphosphate. This invention presents novel process for synthesizing triphosphate oligonucleotides using a diaryl phosphonate as reagent. The process of the present invention is amenable to large-scale, economic 5′-triphosphate oligonucleotide synthesis.
公开/授权文献
- US09035041B2 Process for triphosphate oligonucleotide synthesis 公开/授权日：2015-05-19