发明申请
- 专利标题： METHODS FOR ENHANCING ANTIGEN-SPECIFIC IMMUNE RESPONSES
- 专利标题（中）： 用于增强抗原特异性免疫应答的方法
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申请号： US13388889申请日： 2010-07-28
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公开(公告)号： US20120225090A1公开(公告)日： 2012-09-06
- 发明人: Tzyy-Choou Wu , Chien-Fu Hung , Richard Roden
- 申请人： Tzyy-Choou Wu , Chien-Fu Hung , Richard Roden
- 申请人地址： US MD Baltimore
- 专利权人： THE JOHNS HOPKINS UNIVERSITY
- 当前专利权人： THE JOHNS HOPKINS UNIVERSITY
- 当前专利权人地址： US MD Baltimore
- 国际申请： PCT/US10/43544 WO 20100728
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61P35/00 ; A61K39/12 ; A61P37/04
摘要：
Methods for delivering naked DNA vaccines to enhance immune responses, by improving transfection efficiency without safety concerns associated with live viral vectors, are described. A method may comprise administering to a mammalian subject an effective amount of a papillomavirus pseudovirion, wherein the papillomavirus pseudovirion comprises at least one papillomavirus capsid protein encapsidating a naked DNA vaccine, wherein the naked DNA vaccine comprises a first nucleic acid encoding at least one antigen, thereby enhancing the antigen specific immune response relative to administration of the naked DNA vaccine.
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