发明申请
US20120225428A1 TYPE OF UNIVERSAL PROBE FOR THE DETECTION OF GENOMIC VARIANTS
审中-公开
通用探头类型，用于检测基因组变体
- 专利标题： TYPE OF UNIVERSAL PROBE FOR THE DETECTION OF GENOMIC VARIANTS
- 专利标题（中）： 通用探头类型，用于检测基因组变体
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申请号： US13411902申请日： 2012-03-05
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公开(公告)号： US20120225428A1公开(公告)日： 2012-09-06
- 发明人: Reinhard Beck , Frank Bergmann , Rita Haerteis , Dieter Heindl , Ralf Mauritz , Heiko Walch
- 申请人： Reinhard Beck , Frank Bergmann , Rita Haerteis , Dieter Heindl , Ralf Mauritz , Heiko Walch
- 申请人地址： US IN Indianapolis
- 专利权人： ROCHE DIAGNOSTICS OPERATIONS, INC.
- 当前专利权人： ROCHE DIAGNOSTICS OPERATIONS, INC.
- 当前专利权人地址： US IN Indianapolis
- 优先权： EP11001840.5 20110304
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; G01N21/64
摘要：
The present disclosure relates to a composition comprising a first set of probes and a second set of probes, composed of one or more DNA nucleotide(s) and five or more LNA (locked nucleic acid) nucleotides, wherein the base at a discriminating position differs for a first probe of the first set and a first probe of the second set. The present disclosure relates to the composition comprising a plurality of probes in each of the first and second set of probes, wherein the probes in each set differ in one, two, or three LNA random position(s). Further, the present disclosure relates to a method of detecting genomic variants by means of the aforementioned probes.