发明申请
US20120225844A1 BICYCLIC TRIAZOLE AND PYRAZOLE LACTAMS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS
失效
作为MGLUR5受体的独立调节剂的双相三唑和吡唑类
- 专利标题： BICYCLIC TRIAZOLE AND PYRAZOLE LACTAMS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS
- 专利标题（中）： 作为MGLUR5受体的独立调节剂的双相三唑和吡唑类
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申请号： US13329025申请日： 2011-12-16
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公开(公告)号： US20120225844A1公开(公告)日： 2012-09-06
- 发明人: P. Jeffrey Conn , Craig W. Lindsley , Shaun R. Stauffer , José Manuel Bartolomé-Nebreda , Susana Conde-Ceide , Gregor James Macdonald , Han Min Tong , Carrie K. Jones , Manuel Jesús Alcázar-Vaca , José Ignacio Andrés-Gil , Chrysa Malosh
- 申请人： P. Jeffrey Conn , Craig W. Lindsley , Shaun R. Stauffer , José Manuel Bartolomé-Nebreda , Susana Conde-Ceide , Gregor James Macdonald , Han Min Tong , Carrie K. Jones , Manuel Jesús Alcázar-Vaca , José Ignacio Andrés-Gil , Chrysa Malosh
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61K31/695 ; C07F7/08 ; A61P35/04 ; A61P25/20 ; A61P25/18 ; A61P25/08 ; A61P25/28 ; A61P25/06 ; A61K31/4985 ; A61P25/00
摘要：
In one aspect, the invention relates to bicyclic triazole and pyrazole lactams, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.