A system and method of transmitting and receiving packetized biological sequence data is disclosed. The method includes receiving, at a network interface of a node of a network, a data packet including a first header containing network routing information, a second header containing header information pertaining to the biological sequence data, and a payload containing a compressed version of the biological sequence data. The method further includes extracting at least the compressed version of the biological sequence data from the data packet. In addition, the method includes storing the compressed version of the biological sequence data within a memory of the node.