- 专利标题： BRACHYURY POLYPEPTIDES AND METHODS FOR USE
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申请号： US13460587申请日： 2012-04-30
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公开(公告)号： US20120230948A1公开(公告)日： 2012-09-13
- 发明人: Jeffrey Schlom , Claudia M. Palena , Andrei P. Kozlov , Kwong-yok Tsang
- 申请人： Jeffrey Schlom , Claudia M. Palena , Andrei P. Kozlov , Kwong-yok Tsang
- 专利权人： Health and Human Services,The Government of the United States of America represented by the Sectary of the Department of
- 当前专利权人： Health and Human Services,The Government of the United States of America represented by the Sectary of the Department of
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61K38/20 ; G01N33/574 ; A61K38/19 ; A61P35/00 ; C12N15/63 ; A61K35/76 ; A61K38/21
摘要：
It is disclosed herein that Brachyury is expressed in human tumors, specifically in tumors of the small intestine, stomach, kidney, bladder, uterus, ovary, and testes, as well as in lung, colon and prostate carcinomas. Immunogenic Brachyury polypeptides are disclosed herein. These polypeptides can be used in diagnostic assays for Brachyury expression, as well as for inducing an immune response to Brachyury. Polynucleotides encoding the immunogenic Brachyury polypeptides, vectors including these polypeptides, host cells transformed with these vectors, and methods of using these polypeptides, polynucleotides, vectors, and host cells are provided. Methods of diagnosing a Brachyury-expressing cancer are also provided. Exemplary cancers include small lung, colon, intestine, stomach, kidney, bladder, uterus, ovary, and testes and prostate cancers. Methods of treating cancer are also disclosed.
公开/授权文献
- US08613933B2 Brachyury polypeptides and methods for use 公开/授权日：2013-12-24
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