发明申请
- 专利标题： PROCESS FOR THE PREPARATION OF TAPENTADOL AND INTERMEDIATES THEREOF
- 专利标题（中）： 制备他哌多醇及其中间体的方法
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申请号： US13512989申请日： 2010-11-30
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公开(公告)号： US20120232306A1公开(公告)日： 2012-09-13
- 发明人: Giuseppe Motta , Domenico Vergani , Giorgio Bertolini
- 申请人： Giuseppe Motta , Domenico Vergani , Giorgio Bertolini
- 申请人地址： IT Milano
- 专利权人： Euticals S.P.A.
- 当前专利权人： Euticals S.P.A.
- 当前专利权人地址： IT Milano
- 优先权： ITMI2009A002110 20091201
- 国际申请： PCT/IB10/55499 WO 20101130
- 主分类号： C07C209/78
- IPC分类号： C07C209/78 ; C07C225/16 ; C07C233/43 ; C07C209/68 ; C07C69/63
摘要：
The present invention refers to a new process for the synthesis of tapentadol comprising the quantitative resolution of the racemic mixture (V) to obtain the stereoisomer of (S)-3-(dimethylamino)-2-methyl-1-(3-nitrophenyl)-propan-1-one (VII) according to the Scheme 2 below using the (2R,3R)—O,O′-dibenzoyltartaric chiral acid wherein said resolution is quantitative.The present invention also refers to some intermediate compounds of the new synthesis process of tapentadol.
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