发明申请
- 专利标题： 1,4-OXAZEPINES AS BACE1 AND/OR BACE2 INHIBITORS
- 专利标题（中）： 1,4-OXAZEPINES作为BACE1和/或BACE2抑制剂
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申请号： US13415873申请日： 2012-03-09
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公开(公告)号： US20120238548A1公开(公告)日： 2012-09-20
- 发明人: Emanuele Gabellieri , Wolfgang Guba , Hans Hilpert , Harald Mauser , Alexander V. Mayweg , Mark Rogers-Evans , Didier Rombach , Andrew Thomas , Thomas Woltering , Wolfgang Wostl
- 申请人： Emanuele Gabellieri , Wolfgang Guba , Hans Hilpert , Harald Mauser , Alexander V. Mayweg , Mark Rogers-Evans , Didier Rombach , Andrew Thomas , Thomas Woltering , Wolfgang Wostl
- 优先权： EP11158781.2 20110318
- 主分类号： A61K31/553
- IPC分类号： A61K31/553 ; C07D413/12 ; A61P25/28 ; A61P9/00 ; A61P19/02 ; A61P29/00 ; A61P35/00 ; A61P9/10 ; A61P1/00 ; C07D267/10 ; A61P37/06
摘要：
The present invention relates to 1,4-Oxazepines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
公开/授权文献
- US08748418B2 1,4-oxazepines as BACE1 and/or BACE2 inhibitors 公开/授权日：2014-06-10
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