发明申请
- 专利标题: Inhibiting EPH B-3 Kinase
- 专利标题(中): 抑制EPH B-3激酶
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申请号: US13260990申请日: 2010-03-30
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公开(公告)号: US20120238597A1公开(公告)日: 2012-09-20
- 发明人: Lixin Qiao , Marcie Glicksman , Thomas Gainer , Donald C. Lo , Ross L. Stein , Sungwoon Choi , Gregory D. Cuny
- 申请人: Lixin Qiao , Marcie Glicksman , Thomas Gainer , Donald C. Lo , Ross L. Stein , Sungwoon Choi , Gregory D. Cuny
- 申请人地址: US NC Durham US MA Boston
- 专利权人: DUKE UNIVERSITY,BRIGHAM & WOMEN'S HOSPITAL, INC.
- 当前专利权人: DUKE UNIVERSITY,BRIGHAM & WOMEN'S HOSPITAL, INC.
- 当前专利权人地址: US NC Durham US MA Boston
- 国际申请: PCT/US2010/029209 WO 20100330
- 主分类号: A61K31/437
- IPC分类号: A61K31/437 ; A61P35/02 ; A61P25/00 ; C07D471/04 ; A61P35/00
摘要:
EphB3 kinase inhibitor compounds, including certain pyrazolo[1,5-a]pyridine and imidazo[1,2-a]pyridine compounds, inhibit EphB3 kinase. The EphB3 kinase inhibitor compounds can have greater potency for the inhibition of EphB3 kinase than general kinase inhibitors. Pharmaceutical compositions, such as neuroprotective agents, comprising the EphB3 kinase inhibitor compounds are also provided. The EphB3 kinase inhibitor compounds and pharmaceutical compositions are useful, for example, to provide neuroprotection and/or repair of neuronal tissue damaged during an ischemic event, such as a stroke.
公开/授权文献
- US08927545B2 Inhibiting Eph B-3 kinase 公开/授权日:2015-01-06