发明申请
US20120244140A1 SCREENING METHOD FOR SUBSTANCE CAPABLE OF PROMOTING RECOVERY OF SKIN BARRIER FUNCTION TECHNICAL FIELD
审中-公开
用于促进皮肤屏障功能恢复的物质的筛选方法技术领域
- 专利标题: SCREENING METHOD FOR SUBSTANCE CAPABLE OF PROMOTING RECOVERY OF SKIN BARRIER FUNCTION TECHNICAL FIELD
- 专利标题(中): 用于促进皮肤屏障功能恢复的物质的筛选方法技术领域
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申请号: US13513528申请日: 2010-12-03
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公开(公告)号: US20120244140A1公开(公告)日: 2012-09-27
- 发明人: Toshihiko Hibino , Mami Yamamoto
- 申请人: Toshihiko Hibino , Mami Yamamoto
- 申请人地址: JP Tokyo
- 专利权人: Shiseido Company, Ltd.
- 当前专利权人: Shiseido Company, Ltd.
- 当前专利权人地址: JP Tokyo
- 优先权: JP2009-277034 20091204
- 国际申请: PCT/JP2010/071736 WO 20101203
- 主分类号: A61K38/48
- IPC分类号: A61K38/48 ; G01N33/573 ; A61P17/02 ; C12Q1/37
摘要:
The present invention provides a screening method for a substance capable of promoting recovery of skin barrier function, wherein the method comprises the steps of incubating caspase-14 and prosaposin in the presence of a candidate substance for the substance capable of promoting recovery of skin barrier function, and selecting the candidate substance as the substance capable of promoting recovery of skin barrier function when the degradation of prosaposin into saposin A is promoted significantly compared to a control substance.
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