- 专利标题： CYTOTOXIC BENZODIAZEPINE DERIVATIVES
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申请号： US13397195申请日： 2012-02-15
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公开(公告)号： US20120244171A1公开(公告)日： 2012-09-27
- 发明人: Wei Li , Michael Miller , Nathan Fishkin , Ravi V.J. Chari
- 申请人： Wei Li , Michael Miller , Nathan Fishkin , Ravi V.J. Chari
- 申请人地址： US MA Waltham
- 专利权人： ImmunoGen, Inc.
- 当前专利权人： ImmunoGen, Inc.
- 当前专利权人地址： US MA Waltham
- 主分类号： A61K31/5517
- IPC分类号： A61K31/5517 ; C07K16/28 ; A61K39/395 ; A61P35/00 ; A61P13/12 ; A61P19/08 ; A61P31/00 ; A61P31/12 ; A61P25/28 ; A61P1/18 ; C07D487/04 ; A61P37/00
摘要：
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
公开/授权文献
- US08765740B2 Cytotoxic benzodiazepine derivatives 公开/授权日：2014-07-01
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