发明申请
- 专利标题： TUMOR-SPECIFIC BACTERIAL PROMOTER ELEMENTS
- 专利标题（中）： 肿瘤特异性细菌促进因子
-
申请号： US13321777申请日： 2010-05-28
-
公开(公告)号： US20120244621A1公开(公告)日： 2012-09-27
- 发明人: Siegfried Weiss , Sara Bartels , Holger Loessner , Igor Deyneko , Dirk Bumann , Kathrin Westphal-Daniel
- 申请人： Siegfried Weiss , Sara Bartels , Holger Loessner , Igor Deyneko , Dirk Bumann , Kathrin Westphal-Daniel
- 申请人地址： DE Braunschweig
- 专利权人： HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GmbH
- 当前专利权人： HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GmbH
- 当前专利权人地址： DE Braunschweig
- 优先权： EP09161442.0 20090528
- 国际申请： PCT/EP2010/057452 WO 20100528
- 主分类号： C12N1/21
- IPC分类号： C12N1/21 ; C12N15/70 ; C12N15/74
摘要：
The invention relates to bacterial promoter elements which constitute or which are comprised in promoter regions and which confer tumour specificity to the promoter region activity, resulting in transcription of a transgene, which can be a heterologous or a homologous gene, which transgene is functionally arranged downstream of the promoter region at presence of a host bacterium in tumour tissue, while essentially conferring inactivity of the promoter region and no transcription at presence of the host bacterium in non-tumour tissue. Accordingly, the invention relates to bacterial promoter regions containing these tumour specific promoter elements.
信息查询
IPC分类:
