发明申请
US20120251545A1 Therapeutic Combinations Of Hydroxybenzamide Derivatives As Inhibitors Of HSP90
有权
羟基苯甲酰胺衍生物作为HSP90抑制剂的治疗组合
- 专利标题： Therapeutic Combinations Of Hydroxybenzamide Derivatives As Inhibitors Of HSP90
- 专利标题（中）： 羟基苯甲酰胺衍生物作为HSP90抑制剂的治疗组合
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申请号： US13271678申请日： 2011-10-12
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公开(公告)号： US20120251545A1公开(公告)日： 2012-10-04
- 发明人: Gianni Chessari , Miles Stuart Congreve , Martyn Frederickson , Christopher William Murray , Eva Figueron Navarro , Alison Jo-Anne Woolford
- 申请人： Gianni Chessari , Miles Stuart Congreve , Martyn Frederickson , Christopher William Murray , Eva Figueron Navarro , Alison Jo-Anne Woolford
- 优先权： GB0507474.5 20050413; GB0604111.5 20060301
- 主分类号： A61K31/496
- IPC分类号： A61K31/496 ; A61K31/4035 ; A61P35/00 ; A61K31/5377 ; A61K31/454 ; A61K38/45 ; A61K39/395 ; A61K31/437
摘要：
The invention provides a combination comprising an Hsp90 inhibitor compound of the formula (VII): or tautomer or salt thereof and one or more therapeutic agents selected from topoisomerase I inhibitors; antimetabolites; tubulin targeting agents; DNA binder and topoisomerase II inhibitors; alkylating agents; monoclonal antibodies; anti-hormones; signal transduction inhibitors; proteasome inhibitors; DNA methyl transferases; cytokines; retinoids and HDAC or HAT modulators.
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