发明申请
- 专利标题： BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS
- 专利标题（中）： 双相PYRIDINES和模拟物作为SIRTUIN调节剂
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申请号： US13504134申请日： 2010-10-29
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公开(公告)号： US20120252780A1公开(公告)日： 2012-10-04
- 发明人: Pui Yee Ng , Charles Blum , Lauren McPherson , Robert B. Perni , Chi B. Vu , Mohammed Mahmood Ahmed , Jeremy S. Disch
- 申请人： Pui Yee Ng , Charles Blum , Lauren McPherson , Robert B. Perni , Chi B. Vu , Mohammed Mahmood Ahmed , Jeremy S. Disch
- 国际申请： PCT/US2010/054880 WO 20101029
- 主分类号： A61K31/4375
- IPC分类号： A61K31/4375 ; A61K31/5383 ; C07D519/00 ; C07D471/04 ; A61P3/10 ; A61K31/55 ; A61K31/551 ; A61K31/553 ; A61K31/444 ; A61P3/04 ; C07D498/04 ; A61K31/4985
摘要：
Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
公开/授权文献
- US09556201B2 Bicyclic pyridines and analogs as sirtuin modulators 公开/授权日：2017-01-31
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