An apparatus includes and ampoule and a protective sleeve. The ampoule includes a body portion and an openable end portion. The body portion defines an internal cavity for containment of a substance. The openable end portion is configured to be opened by removal of a distal section, which upon removal creates an opening into the internal cavity of the body portion for liberation of the substance from the internal cavity. The protective sleeve is disposed over at least a portion of the openable end portion. The protective sleeve provides a contamination barrier to prevent contamination of an outer surface of the openable end portion covered by the protective sleeve.