发明申请
- 专利标题： METHODS FOR MODULATING BACTERIAL INFECTION
- 专利标题（中）： 调节细菌感染的方法
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申请号： US13501615申请日： 2010-10-15
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公开(公告)号： US20120276149A1公开(公告)日： 2012-11-01
- 发明人: Dan Littman , Ivaylo Ivanov , Eoin Brodie , Yoshinori Umesaki , Kenya Honda
- 申请人： Dan Littman , Ivaylo Ivanov , Eoin Brodie , Yoshinori Umesaki , Kenya Honda
- 国际申请： PCT/US10/02757 WO 20101015
- 主分类号： A61K35/74
- IPC分类号： A61K35/74 ; A61P31/04 ; A61P37/04 ; A61K38/17
摘要：
The present invention relates to methods for treating or reducing the risk of or preventing diseases caused by or associated with pathogenic bacteria. More particularly, the present invention relates to methods for treating or reducing the risk of or preventing diseases caused by or associated with pathogenic bacteria of the gastrointestinal (GI) tract. The present invention further relates to methods for promoting pathways induced by commensal bacteria of the GI tract that lead to Th17 differentiation, which in turn leads to localized and systemic accumulation of Th17 cells. Compositions and medicaments are also described herein that are used alleviate and/or prevent symptoms associated with diseases caused by or associated with pathogenic bacteria. Accordingly, the compositions, medicaments and methods described herein may be used to address the needs of patients or subjects that would benefit from increased Th17 cell differentiation.
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