发明申请
- 专利标题： MICROORGANISMS FOR THE PRODUCTION OF METHACRYLIC ACID
- 专利标题（中）： 用于生产甲基丙烯酸的微生物
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申请号： US13531377申请日： 2012-06-22
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公开(公告)号： US20120276604A1公开(公告)日： 2012-11-01
- 发明人: Anthony P. Burgard , Mark J. Burk , Robin E. Osterhout , Priti Pharkya
- 申请人： Anthony P. Burgard , Mark J. Burk , Robin E. Osterhout , Priti Pharkya
- 申请人地址： US CA San Diego
- 专利权人： GENOMATICA, INC.
- 当前专利权人： GENOMATICA, INC.
- 当前专利权人地址： US CA San Diego
- 主分类号： C12P7/42
- IPC分类号： C12P7/42 ; C12N1/21
摘要：
The invention provides a non-naturally occurring microbial organism having a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The invention additionally provides a method for producing 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid. The method can include culturing a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid producing microbial organism expressing at least one exogenous nucleic acid encoding a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway enzyme in a sufficient amount and culturing under conditions and for a sufficient period of time to produce 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid.
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