发明申请
US20120282464A1 Spherical Protein Particles and Methods of Making and Using Them
审中-公开
球形蛋白颗粒及其制备和使用方法
- 专利标题： Spherical Protein Particles and Methods of Making and Using Them
- 专利标题（中）： 球形蛋白颗粒及其制备和使用方法
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申请号： US13192345申请日： 2011-07-27
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公开(公告)号： US20120282464A1公开(公告)日： 2012-11-08
- 发明人: Kirill YAKOVLEVSKY , Michael Shamashkin , Nazer Khalaf , Chandrika P. Govardhan , Chu W. Jung
- 申请人： Kirill YAKOVLEVSKY , Michael Shamashkin , Nazer Khalaf , Chandrika P. Govardhan , Chu W. Jung
- 申请人地址： US CA San Diego
- 专利权人： Althea Technologies, Inc.
- 当前专利权人： Althea Technologies, Inc.
- 当前专利权人地址： US CA San Diego
- 主分类号： A61K38/16
- IPC分类号： A61K38/16 ; A61P9/00 ; B32B5/16 ; A61P37/06 ; A61P35/00 ; A61K9/00 ; A61P11/00
摘要：
This invention relates to SPPs, spherical nanocrystalline composite particles or crystalline SPPs of biologically active proteins or compositions, including formulations, comprising such SPPs, spherical nanocrystalline composite particles or crystalline SPPs. More particularly, methods are provided for the production of SPPs, spherical nanocrystalline composite particles or crystalline SPPs of high concentrations of biologically active proteins, and for the preparation of stabilized SPPs, spherical nanocrystalline composite particles or crystalline SPPs for use alone, or in dry or slurry compositions. This invention also relates to methods for stabilization, storage and delivery of biologically active proteins using SPPs, spherical nanocrystalline composite particles or crystalline SPPs. The present invention further relates to methods using SPPs, spherical nanocrystalline composite particles or crystalline SPPs, or compositions or formulations comprising such SPPs, spherical nanocrystalline composite particles or crystalline SPPs, for biomedical applications, including biological delivery to humans and animals.
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