发明申请
- 专利标题： METHOD FOR MAKING POLYPEPTIDES
- 专利标题（中）： 制备多糖的方法
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申请号： US13510363申请日： 2010-11-25
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公开(公告)号： US20120282653A1公开(公告)日： 2012-11-08
- 发明人: Asser Sloth Andersen , Inger Lautrup-Larsen , Per Noergaard
- 申请人： Asser Sloth Andersen , Inger Lautrup-Larsen , Per Noergaard
- 申请人地址： DK Bagsvaerd
- 专利权人： Novo Nordisk A/S
- 当前专利权人： Novo Nordisk A/S
- 当前专利权人地址： DK Bagsvaerd
- 优先权： EP09177095.8 20091125
- 国际申请： PCT/EP2010/068178 WO 20101125
- 主分类号： C12P21/00
- IPC分类号： C12P21/00
摘要：
The invention provides an improved method for producing polypeptides with a C-terminal glycine in a yeast transformant being characterized in having a non functional KEX1 gene. The method is in particular well suited to produce polypeptides with an aromatic amino acid residue attached to the C-terminal glycine. The yeast strain may have further non-functional protease genes selected from PEP4, YPS1, MKCI, YPS3, YPS5, YPS6, YPS7, PRB1, STE13 and KEX2.
公开/授权文献
- US08815541B2 Method for making polypeptides 公开/授权日：2014-08-26
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