Invention Application
- Patent Title: FUNCTIONAL MUTATION IN RESPIRATORY SYNCYTIAL VIRUS
- Patent Title (中): 呼吸道感染病毒中的功能性突变
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Application No.: US13474409Application Date: 2012-05-17
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Publication No.: US20120282673A1Publication Date: 2012-11-08
- Inventor: Hong JIN , Robert Brazas , Bin Lu
- Applicant: Hong JIN , Robert Brazas , Bin Lu
- Applicant Address: US MD Gaithersburg
- Assignee: Medlmmune, LLC
- Current Assignee: Medlmmune, LLC
- Current Assignee Address: US MD Gaithersburg
- Main IPC: C12N7/01
- IPC: C12N7/01

Abstract:
The present invention provides recombinant respiratory syncytial viruses that have an attenuated phenotype and that comprise one or more mutations in the viral P, M2-1 and/or M2-2 proteins, as well as live attenuated vaccines comprising such viruses and nucleic acids encoding such viruses. Recombinant RSV P, M2-1 and M2-2 proteins are described. Methods of producing attenuated recombinant RSV, and methods of quantitating neutralizing antibodies that utilize recombinant viruses of family Paramyxoviridae, are also provided.
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