Invention Application
US20120282673A1 FUNCTIONAL MUTATION IN RESPIRATORY SYNCYTIAL VIRUS 审中-公开
呼吸道感染病毒中的功能性突变

FUNCTIONAL MUTATION IN RESPIRATORY SYNCYTIAL VIRUS
Abstract:
The present invention provides recombinant respiratory syncytial viruses that have an attenuated phenotype and that comprise one or more mutations in the viral P, M2-1 and/or M2-2 proteins, as well as live attenuated vaccines comprising such viruses and nucleic acids encoding such viruses. Recombinant RSV P, M2-1 and M2-2 proteins are described. Methods of producing attenuated recombinant RSV, and methods of quantitating neutralizing antibodies that utilize recombinant viruses of family Paramyxoviridae, are also provided.
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