发明申请
US20120288501A1 SUBSTITUTED BENZAZOLES AND METHODS OF THEIR USE AS INHIBITORS OF RAF KINASE
审中-公开
替代苯扎唑及其作为RAF激酶抑制剂的方法
- 专利标题： SUBSTITUTED BENZAZOLES AND METHODS OF THEIR USE AS INHIBITORS OF RAF KINASE
- 专利标题（中）： 替代苯扎唑及其作为RAF激酶抑制剂的方法
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申请号： US13556907申请日： 2012-07-24
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公开(公告)号： US20120288501A1公开(公告)日： 2012-11-15
- 发明人: Payman Amiri , Wendy Fantl , Barry Haskell Levine , Daniel J. Poon , Savithri Ramurthy , Paul A. Renhowe , Sharadha Subramanian , Leonard Sung
- 申请人： Payman Amiri , Wendy Fantl , Barry Haskell Levine , Daniel J. Poon , Savithri Ramurthy , Paul A. Renhowe , Sharadha Subramanian , Leonard Sung
- 申请人地址： US CA Emeryville
- 专利权人： Novartis Vaccines and Diagnostics, Inc. formerly known as Chiron Corporation
- 当前专利权人： Novartis Vaccines and Diagnostics, Inc. formerly known as Chiron Corporation
- 当前专利权人地址： US CA Emeryville
- 主分类号： A61K31/4439
- IPC分类号： A61K31/4439 ; C07D417/14 ; A61K31/5377 ; A61K33/24 ; A61K31/513 ; A61P35/00 ; A61K31/506 ; A61K31/664 ; A61K31/7068 ; A61K31/519 ; A61K31/4745 ; C07D417/12 ; A61K39/395
摘要：
New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.