发明申请
- 专利标题： NUCLEIC ACID MOLECULES ENCODING ANTI-AMYLOID-BETA ANTIBODIES
- 专利标题（中）： 编码抗淀粉样蛋白抗体的核酸分子
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申请号： US13558256申请日： 2012-07-25
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公开(公告)号： US20120288896A1公开(公告)日： 2012-11-15
- 发明人: Ruth Greferath , Andreas Muhs , Andrea Pfeifer , Claude Nicolau
- 申请人： Ruth Greferath , Andreas Muhs , Andrea Pfeifer , Claude Nicolau
- 申请人地址： CH Lausanne
- 专利权人： AC IMMUNE S.A.
- 当前专利权人： AC IMMUNE S.A.
- 当前专利权人地址： CH Lausanne
- 优先权： EP05027092.5 20051212; EP06014729.5 20060714; EP06020766.9 20061002
- 主分类号： C12N15/13
- IPC分类号： C12N15/13 ; C12P21/02 ; C12N5/10 ; C12N1/21 ; C12N15/63
摘要：
The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).
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