发明申请
US20120289506A1 5-MEMBERED NITROGEN CONTAINING HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
审中-公开
含有异氰酸酯的含有异氰酸酯的五元醇衍生物和含有它们的药物组合物
- 专利标题: 5-MEMBERED NITROGEN CONTAINING HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
- 专利标题(中): 含有异氰酸酯的含有异氰酸酯的五元醇衍生物和含有它们的药物组合物
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申请号: US13494380申请日: 2012-06-12
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公开(公告)号: US20120289506A1公开(公告)日: 2012-11-15
- 发明人: Kazuo Shimizu , Yasushi Takigawa , Hideki Fujikura , Masato Iizuka , Masahiro Hiratochi , Norihiko Kikuchi
- 申请人: Kazuo Shimizu , Yasushi Takigawa , Hideki Fujikura , Masato Iizuka , Masahiro Hiratochi , Norihiko Kikuchi
- 申请人地址: JP Matsumoto-shi
- 专利权人: KISSEI PHARMACEUTICAL CO., LTD.
- 当前专利权人: KISSEI PHARMACEUTICAL CO., LTD.
- 当前专利权人地址: JP Matsumoto-shi
- 优先权: JP2007-104094 20070411
- 主分类号: A61K31/40
- IPC分类号: A61K31/40 ; C07D231/14 ; A61K31/415 ; C07D405/10 ; C07D231/22 ; A61P13/12 ; A61K31/4439 ; A61K31/454 ; C07D413/06 ; A61K31/5377 ; A61P19/06 ; C07D207/34 ; C07D401/04
摘要:
5-membered heterocyclic derivatives represented by general formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, prodrugs thereof, or salts thereof. In the formula (I), T represents nitro, cyano and the like; ring J represents aryl or heteroaryl; Q represents carboxy, 5-tetazolyl and the like; Y represents H, OH, NH2, halogen, haloalkyl and the like; X1 and X2 independently represent CR2 or N; R2 represents H, alkyl and the like; R1 represents halogen, cyano, haloalkyl, A-D-E-G-L-M, —N(-D-L-M)2 and the like, A represents a single bond, O, S and the like; D, G and M independently represent optionally substituted alkylene, cycloalkylene, heterocycloalkylene, arylene, heteroarylene and the like; E and L independently represent a single bond, O, S, COO, SO2 and the like.
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