发明申请
US20120296048A1 Dendritic High-molecular-weight Polymer Drug Carriers and Their Conjugates with Drugs Especially for Treatment of Solid Tumours
有权
树突状高分子量聚合物药物载体及其与药物的共轭物特别用于治疗实体瘤
- 专利标题： Dendritic High-molecular-weight Polymer Drug Carriers and Their Conjugates with Drugs Especially for Treatment of Solid Tumours
- 专利标题（中）： 树突状高分子量聚合物药物载体及其与药物的共轭物特别用于治疗实体瘤
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申请号： US13516607申请日： 2010-12-14
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公开(公告)号： US20120296048A1公开(公告)日： 2012-11-22
- 发明人: Tomas Etrych , Petr Chytil , Jiri Strohalm , Karel Ulbrich , Blanka Rihova
- 申请人： Tomas Etrych , Petr Chytil , Jiri Strohalm , Karel Ulbrich , Blanka Rihova
- 优先权： CZPV2009-844 20091215
- 国际申请： PCT/CZ2010/000131 WO 20101214
- 主分类号： C08F20/56
- IPC分类号： C08F20/56
摘要：
The present invention relates to water-soluble high-molecular-weight polymer drug carriers and their conjugates with drugs, derived from dendrimers of the amidoamine and 2,2-bis(hydroxymethyl)propanoic types, the amino and hydroxy end groups of which are attached to semitelechelic copolymers of N-(2 hydroxypropyl)methacrylamide (HPMA) through biodegradable spacers. The polymer carriers and conjugates enable targeted transport notably of anticancer drugs into solid tumors in which biodegradation, the associated controlled drug release and subsequent elimination of polymer carrier from the organism are provided. The polymer carrier conjugated with a cancerostatic for use in targeted therapy of human tumors.
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