A flash drive protection structure includes a decoration cover and a protective cover. The decoration cover that is made by elastic materials includes a cover block and a receiving space spacedly. The cover block has a cover hole facing the receiving space, and a connecting post is formed inside the receiving space. The protective cover has a first and a second surface, and the protective cover is disposed in the receiving space of the decoration cover through the first surface, while the second surface is exposed outside the decoration cover. The protective cover has a connecting hole at the first surface to connect the connecting post of the decoration cover. Also, the protective cover has a receiving trough toward the cover block, and one end of the flash drive is plugged into the receiving trough, while the other end is plugged into the cover hole of the cover block.