The disclosure provides a method and system for signaling configuration of a Physical Uplink Shared Channel (PUSCH), the system comprises a base station and a target User Equipment (UE). The method comprises: a base station sends Downlink Control Information (DCI) to the target user equipment through a Physical Downlink Control Channel (PUCCH); and the downlink control information includes orthogonal cover code information and/or cyclic shift information for scheduling the physical uplink shared channel in the multi-antenna port transmission and/or single antenna port transmission. It is very adaptable and flexible to use the combination of multiple kinds of information to indicate the orthogonal cover code information in the downlink control information. The UE can obtain the orthogonal cover code information accurately, and the reliability of services can be improved.