发明申请
US20120302627A1 METHOD OF USING ADENOVIRAL VECTORS TO INDUCE AN IMMUNE RESPONSE
审中-公开
使用腺病毒载体诱导免疫应答的方法
- 专利标题： METHOD OF USING ADENOVIRAL VECTORS TO INDUCE AN IMMUNE RESPONSE
- 专利标题（中）： 使用腺病毒载体诱导免疫应答的方法
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申请号： US13568239申请日： 2012-08-07
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公开(公告)号： US20120302627A1公开(公告)日： 2012-11-29
- 发明人: Gary J. Nabel , Cheng Cheng , Wing-Pui Kong , Jason G.D. Gall , C. Richter King
- 申请人： Gary J. Nabel , Cheng Cheng , Wing-Pui Kong , Jason G.D. Gall , C. Richter King
- 申请人地址： US MD Bethesda US MD Gaithersburg
- 专利权人： The United States of America, as represented by the Secretary, Dept. of Health and Human Service,GENVEC, INC.
- 当前专利权人： The United States of America, as represented by the Secretary, Dept. of Health and Human Service,GENVEC, INC.
- 当前专利权人地址： US MD Bethesda US MD Gaithersburg
- 主分类号： A61K31/7088
- IPC分类号： A61K31/7088 ; A61P37/02
摘要：
The invention provides a method of inducing an immune response against a human immunodeficiency virus (HIV) in a mammal. The method comprises administering to the mammal an adenoviral vector composition comprising one or more adenoviral vectors encoding two or more different HIV antigens, the production of which induces an immune response against HIV in the mammal. The invention also provides an adenoviral vector composition comprising four adenoviral vectors encoding an HIV clade A Env protein, an HIV clade B Env protein, an HIV clade C Env protein, and a fusion protein comprising an HIV clade B Gag protein and Pol protein, respectively.
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