发明申请
- 专利标题： HETEROCYCLIC INHIBITORS OF NECROPTOSIS
- 专利标题（中）： 异位抑制剂的非特异性抑制剂
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申请号： US13589867申请日： 2012-08-20
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公开(公告)号： US20120309795A1公开(公告)日： 2012-12-06
- 发明人: Gregory D. Cuny , Xin Teng , Junying Yuan , Alexei Degterev , John A. Porco, JR.
- 申请人： Gregory D. Cuny , Xin Teng , Junying Yuan , Alexei Degterev , John A. Porco, JR.
- 主分类号： A61K31/433
- IPC分类号： A61K31/433 ; A61K31/40 ; C07D417/12 ; C07D285/06 ; A61P9/10 ; A61P25/00 ; A61P1/16 ; A61P35/00 ; A61P1/18 ; A61P25/28 ; A61K31/4439 ; C07D207/34
摘要：
The invention features a series of heterocyclic derivatives that inhibit tumor necrosis factor alpha (TNF-α) induced necroptosis. The heterocyclic compounds of the invention are described by Formulas (I) and (Ia)-(Ie) and are shown to inhibit TNF-α induced necroptosis in FADD-deficient variant of human Jurkat T cells. The invention further features pharmaceutical compositions featuring the compounds of the invention. The compounds and compositions of the invention may also be used to treat disorders where necroptosis is likely to play a substantial role.
公开/授权文献
- US08658689B2 Heterocyclic inhibitors of necroptosis 公开/授权日：2014-02-25
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