发明申请
- 专利标题： LARGE SCALE GENERATION OF FUNCTIONAL MEGAKARYOCYTES AND PLATELETS FROM HUMAN EMBRYONIC STEM CELLS UNDER STROMAL-FREE CONDITIONS
- 专利标题（中）： 在无条件条件下从人类胚胎干细胞中大量生成功能性大分子和片段
-
申请号： US13512827申请日： 2010-12-03
-
公开(公告)号： US20120315338A1公开(公告)日： 2012-12-13
- 发明人: Feng Li , Shi-Jiang Lu
- 申请人： Feng Li , Shi-Jiang Lu
- 申请人地址： US MA Marlborough
- 专利权人： Stem Cell & Regenerative Medicine International, Inc.
- 当前专利权人： Stem Cell & Regenerative Medicine International, Inc.
- 当前专利权人地址： US MA Marlborough
- 国际申请： PCT/US10/58990 WO 20101203
- 主分类号： C12N5/078
- IPC分类号： C12N5/078 ; A61K35/14 ; A61P7/04 ; G01N33/566
摘要：
The present invention provides a method of generating megakaryocytes and platelets. In various embodiments, method involves the use of human embryonic stem cell derived hemangioblasts for differentiation into megakaryocytes and platelets under serum and stromal-free condition. In this system, hESCs are directed towards megakaryocytes through embryoid body formation and hemangioblast differentiation. Further provided is a method of treating a subject in need of platelet transfusion.
公开/授权文献
信息查询
