发明申请
US20120316127A1 METHOD OF MANUFACTURING COATING AGENT FOR DRUG RELEASING STENT AND COATING AGENT FOR DRUG RELEASING STENT MANUFACTURED THEREBY 审中-公开
制造用于药物释放的涂层剂的方法和用于药物释放的涂层剂

  • 专利标题: METHOD OF MANUFACTURING COATING AGENT FOR DRUG RELEASING STENT AND COATING AGENT FOR DRUG RELEASING STENT MANUFACTURED THEREBY
  • 专利标题(中): 制造用于药物释放的涂层剂的方法和用于药物释放的涂层剂
  • 申请号: US13491145
    申请日: 2012-06-07
  • 公开(公告)号: US20120316127A1
    公开(公告)日: 2012-12-13
  • 发明人: Kyong-Min SHINKun Na
  • 申请人: Kyong-Min SHINKun Na
  • 优先权: KR10-2011-0054540 20110607
  • 主分类号: A61K31/7068
  • IPC分类号: A61K31/7068 A61P35/00 B05D5/00
METHOD OF MANUFACTURING COATING AGENT FOR DRUG RELEASING STENT AND COATING AGENT FOR DRUG RELEASING STENT MANUFACTURED THEREBY
摘要:
This invention relates to a method of manufacturing a coating agent for a drug releasing stent and to a coating agent for a drug releasing stent manufactured thereby. This method includes (1) dissolving polyurethane in tetrahydrofuran, (2) dissolving pluronic F-127 in tetrahydrofuran, (3) dissolving a gemcitabine compound in ethanol, (4) mixing these three solutions obtained in (1) to (3) thus preparing a solution mixture, (5) applying the solution mixture obtained in (4) on a stent coated with a Teflon film, (6) drying the stent of (5) for a predetermined period of time and then immersing the stent in a polyurethane solution in tetrahydrofuran, and (7) removing the stent immersed in (6) from the polyurethane solution and then drying the stent, so that the rate of release of an anti-cancer drug applied on the stent can be continuously and maximally improved thereby maximizing anti-cancer efficacy.
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