发明申请
US20120316204A1 COMPOUNDS AND COMPOSITIONS FOR STABILIZING HYPOXIA INDUCIBLE FACTOR-2 ALPHA AS A METHOD FOR TREATING CANCER
有权
用于稳定HYPOXIA可诱导因子-2 ALPHA的化合物和组合物作为治疗癌症的方法
- 专利标题： COMPOUNDS AND COMPOSITIONS FOR STABILIZING HYPOXIA INDUCIBLE FACTOR-2 ALPHA AS A METHOD FOR TREATING CANCER
- 专利标题（中）： 用于稳定HYPOXIA可诱导因子-2 ALPHA的化合物和组合物作为治疗癌症的方法
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申请号： US13489400申请日： 2012-06-05
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公开(公告)号： US20120316204A1公开(公告)日： 2012-12-13
- 发明人: Robert Shalwitz , Joseph H. Gardner
- 申请人： Robert Shalwitz , Joseph H. Gardner
- 申请人地址： US OH Cincinnati
- 专利权人： Akebia Therapeutics Inc.
- 当前专利权人： Akebia Therapeutics Inc.
- 当前专利权人地址： US OH Cincinnati
- 主分类号： A61K31/4418
- IPC分类号： A61K31/4418 ; A61P35/00 ; C07D213/81
摘要：
Disclosed herein is {[5-(3-fluorophenyl)-3-hydroxypyridine-2-carbonyl]-amino}acetic acid and the ester and amide prodrugs thereof, that can stabilize hypoxia inducible factor-2 alpha (HIF-2α) and thereby provide a method for treating cancer. Further disclosed are compositions which comprise {[5-(3-fluorophenyl)-3-hydroxypyridine-2-carbonyl]-amino}acetic acid and/or a prodrug thereof which can be used to treat cancer.
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