发明申请
US20120321617A1 HUMANIZED ANTI-IL 10 ANTIBODIES FOR THE TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)
有权
用于治疗系统性红斑狼疮（SLE）的人类抗IL10抗体
- 专利标题： HUMANIZED ANTI-IL 10 ANTIBODIES FOR THE TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)
- 专利标题（中）： 用于治疗系统性红斑狼疮（SLE）的人类抗IL10抗体
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申请号： US13512712申请日： 2010-11-30
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公开(公告)号： US20120321617A1公开(公告)日： 2012-12-20
- 发明人: Frank Osterroth , Christoph Uherek , Christoph Bruecher , Peter Röttgen , Benjamin Daelken , André Engling , Chantal Zuber , Niklas Czeloth
- 申请人： Frank Osterroth , Christoph Uherek , Christoph Bruecher , Peter Röttgen , Benjamin Daelken , André Engling , Chantal Zuber , Niklas Czeloth
- 申请人地址： DE Dreieich
- 专利权人： BIOTEST AG
- 当前专利权人： BIOTEST AG
- 当前专利权人地址： DE Dreieich
- 优先权： GB0920933.9 20091130; GB0920940.4 20091130; GB0920942.0 20091130
- 国际申请： PCT/EP2010/068569 WO 20101130
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C12N15/13 ; A61P19/04 ; C07K17/00 ; G01N33/566 ; C12N1/21 ; C12N5/10 ; C12P21/02 ; C12N5/078 ; C07K16/24 ; C12N15/63
摘要：
Provided is a humanized or chimeric antibody or fragment thereof capable of binding to interleukin-10 (IL-10), wherein said antibody or fragment thereof: (i) binds to the same region of IL-10 as the 1L-10 receptor α (IL-I10Ra) and is not capable of binding IL-10 when the IL-10 is bound to the IL-10 receptor; and (ii) binds to IL-10 in homodimeric form by binding a discontinuous epitope comprising residues of both monomers. Further provided are related products and methods involving the use of the antibody or fragment thereof.
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