Invention Application
- Patent Title: PRODUCTION OF GLYCOPROTEINS WITH REDUCED O-GLYCOSYLATION
- Patent Title (中): 生产具有减少的O-糖苷化的糖蛋白
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Application No.: US13530768Application Date: 2012-06-22
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Publication No.: US20120322101A1Publication Date: 2012-12-20
- Inventor: Piotr Bobrowicz , W. James Cook , Warren Kett
- Applicant: Piotr Bobrowicz , W. James Cook , Warren Kett
- Applicant Address: US NH Lebanon
- Assignee: GLYCOFI, INC.
- Current Assignee: GLYCOFI, INC.
- Current Assignee Address: US NH Lebanon
- Main IPC: C12P21/00
- IPC: C12P21/00
Abstract:
A method is described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of an inhibitor of Pmt-mediated O-linked glycosylation and/or in the presence of one or more α-1,2-mannosidases.
Public/Granted literature
- US08795984B2 Production of glycoproteins with reduced O-glycosylation Public/Granted day:2014-08-05
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