Systems and methods for resource management in distributed femtocell networks include categorizing a clients into a first category that includes interference-insensitive clients and a second category that includes interference-sensitive clients and sub-categorizing the clients in the second category into a low-sensitivity sub-category and a high-sensitivity sub-category. A desired local reuse zone is determined based on a number of interference-insensitive clients and a common reuse zone size is determined based on transmissions from neighboring base stations. Positions for a local reuse zone, transition zone, and isolation zone within a frame are allocated based on the desired local reuse zone and the common reuse zone size. Probing is used on a coarse time scale to determine whether network conditions have changed and, if network conditions have changed, a fine time scale is used for probing to adjust zone sizes according to the changed network conditions.