发明申请
- 专利标题: INHIBITORS OF HEPATITIS C VIRUS NS5B POLYMERASE
- 专利标题(中): HEPATITIS C VIRUS NS5B聚合酶抑制剂
-
申请号: US13582240申请日: 2011-03-02
-
公开(公告)号: US20120328569A1公开(公告)日: 2012-12-27
- 发明人: Casey Cameron McComas , Nigel J. Liverton , Richard Soll , Peng Li , Xuanjia Peng , Hao Wu , Frank Narjes , Joerg Habermann , Uwe Koch , Shilan Liu
- 申请人: Casey Cameron McComas , Nigel J. Liverton , Richard Soll , Peng Li , Xuanjia Peng , Hao Wu , Frank Narjes , Joerg Habermann , Uwe Koch , Shilan Liu
- 优先权: CNPCT/CN2010/070831 20100302; CNPCT/CN2010/080332 20101227
- 国际申请: PCT/CN11/00332 WO 20110302
- 主分类号: A61K31/343
- IPC分类号: A61K31/343 ; A61K38/21 ; A61K31/7056 ; C07D407/12 ; A61K31/4025 ; C07D405/12 ; A61K31/4178 ; C07D413/10 ; A61K31/422 ; C07D417/10 ; A61K31/428 ; A61K31/427 ; A61K31/4245 ; A61K31/423 ; A61K31/41 ; C07D471/04 ; A61K31/437 ; C07D513/04 ; C07D498/04 ; A61K31/517 ; C07D487/04 ; A61K31/4985 ; A61K31/519 ; A61K31/549 ; A61K31/5377 ; A61P31/14 ; C07D307/84
摘要:
Disclosed are compounds of formula (I) that are used as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.