发明申请
US20120329996A1 Optimized Monoclonal Antibodies against Tissue Factor Pathway Inhibitor (TFPI)
有权
针对组织因子途径抑制剂（TFPI）的优化单克隆抗体
- 专利标题： Optimized Monoclonal Antibodies against Tissue Factor Pathway Inhibitor (TFPI)
- 专利标题（中）： 针对组织因子途径抑制剂（TFPI）的优化单克隆抗体
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申请号： US13582401申请日： 2011-03-01
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公开(公告)号： US20120329996A1公开(公告)日： 2012-12-27
- 发明人: Zhuozhi Wang , Junliang Pan , Joanna Grudzinska , Christian Votsmeier , Jan Tebbe , Joerg Birkenfeld , Nina Wobst , Simone Brueckner , Susanne Steinig , Peter Scholz
- 申请人： Zhuozhi Wang , Junliang Pan , Joanna Grudzinska , Christian Votsmeier , Jan Tebbe , Joerg Birkenfeld , Nina Wobst , Simone Brueckner , Susanne Steinig , Peter Scholz
- 国际申请： PCT/US11/26766 WO 20110301
- 主分类号： C07K16/18
- IPC分类号： C07K16/18
摘要：
Isolated monoclonal antibodies that bind human tissue factor pathway inhibitor (TFPI) are provided. Isolated nucleic acid molecules encoding monoclonal antibodies that bind TFPI are also contemplated. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treating deficiencies or defects in coagulation by administration of the antibodies are also provided. Methods of producing the antibodies are also provided.
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