发明申请
US20120330048A1 Lycopene Intermediate 1, 3, 6, 10-Tetra-Double Bond Pentadec-Carbon Phosphonate as well as Preparation Method and Use Thereof
有权
番茄红素中间体1,3,6,10-四 - 双键十五碳膦酸酯及其制备方法和用途
- 专利标题： Lycopene Intermediate 1, 3, 6, 10-Tetra-Double Bond Pentadec-Carbon Phosphonate as well as Preparation Method and Use Thereof
- 专利标题（中）： 番茄红素中间体1,3,6,10-四 - 双键十五碳膦酸酯及其制备方法和用途
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申请号： US13583635申请日： 2011-03-09
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公开(公告)号： US20120330048A1公开(公告)日： 2012-12-27
- 发明人: Xuejun Lao , Runpu Shen , Weidong Ye , Xiaohua Song , Luo Liu , Chunlei Wu , Yibin Wu , Liujiang Hu
- 申请人： Xuejun Lao , Runpu Shen , Weidong Ye , Xiaohua Song , Luo Liu , Chunlei Wu , Yibin Wu , Liujiang Hu
- 申请人地址： CN Shaoxing, Zhejiang CN Shaoxing, Zhejiang
- 专利权人： UNIVERSITY OF SHAOXING,ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY
- 当前专利权人： UNIVERSITY OF SHAOXING,ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY
- 当前专利权人地址： CN Shaoxing, Zhejiang CN Shaoxing, Zhejiang
- 优先权： CN201010120583.3 20100309
- 国际申请： PCT/CN2011/071657 WO 20110309
- 主分类号： C07F9/40
- IPC分类号： C07F9/40
摘要：
The invention relates to a novel important lycopene intermediate 3,7, 11-trimethyl-1,3,6,10-tetraene-dodecyl diethyl phosphonate. A current lycopene intermediate 2,4,6,10-tetra-double bond pentadec-carbon phosphonate is difficult to synthesize. The invention provides a novel intermediate, which has the following synthesis steps of: preparing 2,6,10-trimethyl-3,5,9-undecane triene-1-aldehyde from pseudoionone; preparing 2,6,10-trimethyl-2,5,9-undecane triene-1-aldehyde from the 2,6,10-trimethyl-3, 5,9-undecane triene-1-aldehyde; and subjecting the 2,6,10-trimethyl-2,5,9-undecane triene-1-aldehyde and tetraethyl methylenediphosphonate to condensation reaction to obtain target product. The invention can generate novel intermediate from raw material pseudoionone only by four reactions, thus the reactions are easy to control and great industrial value are achieved.
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