Provided are skin treatment compositions comprising an Oenothera biennis oil in an amount of about 1% v/v to about 30% v/v, a vitamin B12 in an amount of about 0.07% m/v to about 1.0% m/v, and a vitamin E in an amount of about 4% m/v to about 12% m/v. Also provided are methods for treating eczema in a mammal through the application of the skin treatment compositions to an area on the mammal's skin that contains one or more signs of eczema.