发明申请
- 专利标题： Methods for Diagnosing The Malignant Potential of Pancreatic Cystic Lesions
- 专利标题（中）： 诊断胰腺囊性病变恶性潜力的方法
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申请号： US13519766申请日： 2010-12-30
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公开(公告)号： US20130005598A1公开(公告)日： 2013-01-03
- 发明人: Brian B. Haab , Diane Simeone
- 申请人： Brian B. Haab , Diane Simeone
- 申请人地址： US MI Ann Arbor US MI Grand Rapids
- 专利权人： The Regents of the University of Michigan,Van Andel Research Institute
- 当前专利权人： The Regents of the University of Michigan,Van Andel Research Institute
- 当前专利权人地址： US MI Ann Arbor US MI Grand Rapids
- 国际申请： PCT/US10/62534 WO 20101230
- 主分类号： G01N33/574
- IPC分类号： G01N33/574 ; C40B30/04 ; A61B5/153 ; C40B40/10
摘要：
A method of diagnosing the malignant potential of a pancreatic cystic lesion in a subject including: detecting a glycan alteration in MUC5AC in a sample of pancreatic cystic lesion fluid from a subject, determining whether the glycan alteration is differentially present in the sample, and diagnosing the malignant potential of the pancreatic cystic lesion. A method of diagnosing the malignant potential of a pancreatic cystic lesion in a subject including: (a) detecting a glycan alteration in MUC5AC in a sample of pancreatic cystic lesion fluid from a subject, (b) detecting CA 19-9 in the sample, (c) determining whether the glycan alteration and CA 19-9 are differentially present in the sample, and (d) diagnosing the malignant potential of the pancreatic cystic lesion. Related methods of treatment and kits also are included.