Systems and methods for binding of cryptographic content using unique device characteristics with server heuristics in accordance with embodiments of the invention are disclosed. One embodiment includes a processor and memory includes collecting a combination of device characteristics that uniquely identify the device using information stored on the device and accessible to the device using the device processor, generating device match data based upon the collected combination of device characteristics using the device processor, generating a device protection key using the device match data, encrypting the cryptographic data using the device protection key, and storing the encrypted cryptographic data in device memory using the device processor.