- 专利标题： COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
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申请号： US13531461申请日： 2012-06-22
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公开(公告)号： US20130018035A1公开(公告)日： 2013-01-17
- 发明人: Somhairle MacCormick , Pierre-Henri Storck , Michael Paul Mortimore , Jean-Damien Charrier , Ronald Knegtel , Stephen Clinton Young , Joanne Pinder , Steven John Durrant
- 申请人： Somhairle MacCormick , Pierre-Henri Storck , Michael Paul Mortimore , Jean-Damien Charrier , Ronald Knegtel , Stephen Clinton Young , Joanne Pinder , Steven John Durrant
- 申请人地址： US MA Cambridge
- 专利权人： VERTEX PHARMACEUTICALS INCORPORATED
- 当前专利权人： VERTEX PHARMACEUTICALS INCORPORATED
- 当前专利权人地址： US MA Cambridge
- 主分类号： A61K31/4985
- IPC分类号： A61K31/4985 ; A61P35/00 ; C07D487/04
摘要：
The present invention relates to pyrrolopyrazines compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: wherein the variables are as defined herein.
公开/授权文献
- US08822469B2 Pyrrolo[2,3-B]pyrazines useful as inhibitors of ATR kinase 公开/授权日：2014-09-02
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