发明申请
US20130028890A1 METHOD FOR DETECTING REGULATORY T CELLS USING EXPRESSION OF FOLATE RECEPTOR 4 AS INDICATOR, METHOD FOR TREATING DISEASES USING THE DETECTION METHOD, PHARMACEUTICAL COMPOSITION FOR IMMUNOSTIMULATION, AND METHOD FOR TREATING DISEASES USING THE COMPOSITION 审中-公开
使用作为指示剂的脂肪酸受体4的表达来检测调节性T细胞的方法,使用检测方法治疗疾病的方法,用于免疫的药物组合物和使用组合物治疗疾病的方法

  • 专利标题: METHOD FOR DETECTING REGULATORY T CELLS USING EXPRESSION OF FOLATE RECEPTOR 4 AS INDICATOR, METHOD FOR TREATING DISEASES USING THE DETECTION METHOD, PHARMACEUTICAL COMPOSITION FOR IMMUNOSTIMULATION, AND METHOD FOR TREATING DISEASES USING THE COMPOSITION
  • 专利标题(中): 使用作为指示剂的脂肪酸受体4的表达来检测调节性T细胞的方法,使用检测方法治疗疾病的方法,用于免疫的药物组合物和使用组合物治疗疾病的方法
  • 申请号: US13617027
    申请日: 2012-09-14
  • 公开(公告)号: US20130028890A1
    公开(公告)日: 2013-01-31
  • 发明人: Shimon SakaguchiKeiji HirotaTomoyuki Yamaguchi
  • 申请人: Shimon SakaguchiKeiji HirotaTomoyuki Yamaguchi
  • 申请人地址: JP Saitama-ken JP Kyoto-shi
  • 专利权人: RIKEN,KYOTO UNIVERSITY
  • 当前专利权人: RIKEN,KYOTO UNIVERSITY
  • 当前专利权人地址: JP Saitama-ken JP Kyoto-shi
  • 优先权: JP2005-134279 20050502
  • 主分类号: A61K39/395
  • IPC分类号: A61K39/395 A61P37/04 A61P35/00
METHOD FOR DETECTING REGULATORY T CELLS USING EXPRESSION OF FOLATE RECEPTOR 4 AS INDICATOR, METHOD FOR TREATING DISEASES USING THE DETECTION METHOD, PHARMACEUTICAL COMPOSITION FOR IMMUNOSTIMULATION, AND METHOD FOR TREATING DISEASES USING THE COMPOSITION
摘要:
An object of the present invention is to provide a technique to distinguish between Treg cells and activated T cells in a live state. Another object of the present invention is to provide a pharmaceutical composition for immunostimulation that can reduce the number of Treg cells in vivo and effectively express the immune response of activated T cells.In the method of the present invention, Treg cells are detected from test cells containing (i) regulatory T cells and (ii) at least one type of cell selected from the group consisting of naive T cells and activated T cells, wherein expressions of folate receptor 4 on the surfaces of cells are measured and Treg cells are detected using the expressions as an indicator. The present invention uses anti-folate receptor 4 antibody or folate receptor 4-binding fragment as an active ingredient contained in a pharmaceutical composition for immunostimulation.
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