发明申请
US20130029974A1 6,7-DIHYDROIMIDAZO[1,5-A]PYRAZIN-8(5H)-ONE DERIVATIVES AS PROTEIN KINASE MODULATORS
有权
6,7-DIHYDROIMIDAZO [1,5-A]吡嗪-8(5H) - 酮衍生物作为蛋白激酶调节剂
- 专利标题: 6,7-DIHYDROIMIDAZO[1,5-A]PYRAZIN-8(5H)-ONE DERIVATIVES AS PROTEIN KINASE MODULATORS
- 专利标题(中): 6,7-DIHYDROIMIDAZO [1,5-A]吡嗪-8(5H) - 酮衍生物作为蛋白激酶调节剂
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申请号: US13575181申请日: 2011-01-21
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公开(公告)号: US20130029974A1公开(公告)日: 2013-01-31
- 发明人: Danilo Mirizzi , Sten Christian Orrenius , Paolo Trifirò
- 申请人: Danilo Mirizzi , Sten Christian Orrenius , Paolo Trifirò
- 申请人地址: IT Nerviano (MI)
- 专利权人: NERVIANO MEDICAL SCIENCES S.R.L.
- 当前专利权人: NERVIANO MEDICAL SCIENCES S.R.L.
- 当前专利权人地址: IT Nerviano (MI)
- 优先权: EP10152132.6 20100129
- 国际申请: PCT/EP2011/050846 WO 20110121
- 主分类号: A61K31/4985
- IPC分类号: A61K31/4985 ; A61K31/55 ; C40B40/04 ; A61K31/5377 ; A61P35/00 ; A61P31/00 ; C07D487/04 ; A61K31/541
摘要:
There are provided 3,5-disubstituted derivatives of 6,7-dihydroimidazo[1,5-a]pyrazin-8(5H)-one compounds of formula (I) or a pharmaceutically acceptable salt thereof as defined in the present specification, which modulate the activity of protein kinases. The compounds are therefore useful in treating diseases caused by dysregulated protein kinase activity. In particular, such diseases to be treated with a compound of formula (I) of the present invention is one caused by and/or associated with disregulated protein kinase activity selected from the group consisting of cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders. The present invention also relates to processes for preparing the compounds of formula (I), combinatorial libraries thereof, pharmaceutical compositions comprising them, and methods of treating diseases utilizing pharmaceutical compositions comprising a compound of formula (I).