Provided are an image diagnosis apparatus and an image diagnosis method using the same. The image diagnosis apparatus includes an X-ray image tomosynthesis device fixing an object using an object fixing unit, the X-ray image tomosynthesis device generating an image tomosynthesis signal by irradiating a plurality of X-rays into the object, a photoacoustic image device fixing the object using the object fixing unit, the photoacoustic image device generating an ultrasonic signal by scanning the object using a photoacoustic light source, an image processing device for processing image signals transmitted from the X-ray image tomosynthesis device and the photoacoustic image device to generate a three-dimensional (3D) image, and a display device for displaying the 3D image generated from the image processing device. The image diagnosis apparatus may realize internal tissues of the object into a clear 3D image.