发明申请
- 专利标题： pH-SENSITIVE NANOPARTICLES FOR ORAL INSULIN DELIVERY
- 专利标题（中）： 用于口服胰岛素递送的pH敏感纳米颗粒
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申请号： US13561106申请日： 2012-07-30
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公开(公告)号： US20130034589A1公开(公告)日： 2013-02-07
- 发明人: Lijuan ZHANG , Li LING , Li Ying ZHOU , Zhi Min WU , Xin Dong GUO , Wei JIANG , Qian LUO , Yu QIAN
- 申请人： Lijuan ZHANG , Li LING , Li Ying ZHOU , Zhi Min WU , Xin Dong GUO , Wei JIANG , Qian LUO , Yu QIAN
- 申请人地址： HK Hong Kong
- 专利权人： NANO AND ADVANCED MATERIALS INSTITUTE LIMITED
- 当前专利权人： NANO AND ADVANCED MATERIALS INSTITUTE LIMITED
- 当前专利权人地址： HK Hong Kong
- 主分类号： A61K9/14
- IPC分类号： A61K9/14 ; A61K38/28 ; A61P3/10 ; B82Y40/00 ; B82Y5/00
摘要：
The present invention discloses the pH-sensitive nanoparticles composed of pH-sensitive polymer, hydrophobic material, internal stabilizer, external stabilizer content and insulin drug. The present invention also includes a method for preparation of pH-sensitive nanoparticles, in particular, a multiple emulsions solvent evaporation method. The pH-sensitive nanoparticles of the present invention show good pH-sensitive property with 100-300 nanometer particle size. Significant decrease in blood glucose level is observed in streptozotocin (STZ)-induced diabetic rats and the bioavailability of insulin is more than 10% after oral administration of the insulin-loaded pH-sensitive nanoparticles.
公开/授权文献
- US08859004B2 pH-sensitive nanoparticles for oral insulin delivery 公开/授权日：2014-10-14
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