发明申请
- 专利标题： METHODS FOR DIAGNOSIS, PROGNOSIS AND METHODS OF TREATMENT
- 专利标题（中）： 诊断，预防和治疗方法的方法
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申请号： US13566991申请日： 2012-08-03
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公开(公告)号： US20130035253A1公开(公告)日： 2013-02-07
- 发明人: David B. Rosen , Santosh K. Putta , Brent Louie , Norman Purvis
- 申请人： David B. Rosen , Santosh K. Putta , Brent Louie , Norman Purvis
- 申请人地址： US CA South San Francisco
- 专利权人： Nodality, Inc. A Delaware Corporation
- 当前专利权人： Nodality, Inc. A Delaware Corporation
- 当前专利权人地址： US CA South San Francisco
- 主分类号： G01N33/574
- IPC分类号： G01N33/574 ; G01N27/62 ; C40B30/04 ; G01N21/64
摘要：
The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations.
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