- 专利标题： CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS CLUMPING FACTOR A IN COMPLEX WITH FIBRINOGEN DERIVED PEPTIDE AND USES THEREOF
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申请号： US13605567申请日： 2012-09-06
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公开(公告)号： US20130035476A1公开(公告)日： 2013-02-07
- 发明人: Magnus Hook , Ya-Ping Ko , Emanuel Smeds , Vannakambadi K. Ganesh
- 申请人： Magnus Hook , Ya-Ping Ko , Emanuel Smeds , Vannakambadi K. Ganesh
- 申请人地址： US TX College Station
- 专利权人： THE TEXAS A & M UNIVERSITY SYSTEM
- 当前专利权人： THE TEXAS A & M UNIVERSITY SYSTEM
- 当前专利权人地址： US TX College Station
- 主分类号： C07K16/12
- IPC分类号： C07K16/12
摘要：
The present invention discloses crystal structure of Staphylococcus aureus Clumping factor A (ClfA) in complex with fibrinogen (Fg) derived peptide. Also, the present invention also discloses the use of this structure in the design of ClfA targeted vaccines and therapeutic agents (including monoclonal antibodies). In addition, the present invention discloses isolated and purified engineered Staphylococcus clumping factor A protein (ClfA) with a stabilized, closed conformation and immunogenic compositions thereof including methods of treating a Staphylococcus infection in an individual.