A method for calibrating in situ a plurality of printheads in an imaging device has been developed. Firing signals operate a plurality of printheads to form ink test patterns on an image receiving member. Reflectance measurements of light reflected from the test patterns and optical density measurements for a portion of the patterns formed by only one printhead in the plurality of printheads are used to adjust the firing signals and enable the printheads to print within a predetermined range about an average reflectance value and a predetermined optical density.